A 3-year postdoctoral researcher position is available at the Department of Immunology (IMM) at Oslo University Hospital Rikshospitalet, led by group Leader Jo Waaler, head of the Cell Signaling and Drug Discovery research group at IMM: www.ous-research.no/waaler. The research group is also associated with the RCN Centre of Excellence (SFF) - Hybrid Technology Hub - Centre for Organ on a Chip-Technology: www.med.uio.no/hth/english.

This position focuses on the pharmacological inhibition of TNKS and its blockade of disease-promoting WNT and YAP cell signaling pathways. Our translational research aims to achieve two objectives: 1) understanding how TNKS inhibition enhances sensitivity to metastatic melanoma immunotherapy and exerts anti-fibrotic effects in lung fibrosis, and 2) advancing our preclinical drug candidate toward clinical trials, an effort supported by our newly initiated company, Odin Therapeutics.

The successful candidate will use immune-competent mouse models to study the synergistic effects of TNKS inhibition combined with immune checkpoint blockade in metastatic melanoma. Additionally, the candidate will employ cutting-edge technologies, including cell culture, patient samples, and animal models, to investigate TNKS inhibition in lung fibrosis. Applicants should have a strong background in immunology and experience with cell culture, animal models, and flow cytometry.

Oslo University Hospital is a workplace with great diversity. We believe this is crucial for solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and we encourage all qualified candidates, regardless of background, to apply!

Key tasks

Conduct cell culture experiments.
Perform dendritic cell and T cell migration assays.
T cell and macrophage “killing assays”.
Carry out experiments using human lung patient material.
Design, perform and analyze animal experiments.
Isolation of lung cells and immune cell populations.
Perform flow cytometry, immune cell phenotyping and scRNA sequencing.
Conduct immunoassays/ELISA and multiplex ELISA.
Basic laboratory and cell signaling pathway analysis techniques: i.e. treatment with small-molecule inhibitors and siRNA, CRISPR-Cas9 gene knockout, real-time RT-qPCR, RNA sequencing, Western blot analysis and immunofluorescence/immunohistochemistry/microscopy.
Oversee project management and supervise master's and PhD students.
Publish scientific papers and present results at international conferences.

Qualifications

Ph.D. degree or equivalent in immunology, molecular medicine, or molecular biology Extensive experience in immunology related to tumor immunotherapy and/or fibrosis biology.
Practical experience with cell culture and animal experiments, as well as most of the methods described under "key tasks".
Experience with cell signaling pathway analysis.
Flexibility and ability to work in a team as well as independently.

The application must include

Application letter, including research interests and the motivations for applying for this position, a description of experience with relevant techniques listed under “key tasks”, project management experience and finally personal suitability and motivation for the position.
CV summarizing education, positions held, details of academic work and other qualifying activities.
Full list of publications.
Copies of educational certificates and transcripts of records.
Names and contact details of 2 referees, stating relation to candidate, e-mail and phone number.
In the evaluation of the applications, emphasis will be put on the applicant's academic and personal qualifications to carry out the project within an allocated time frame.
The application letter and CV should be in English or in a Scandinavian language.

Personal qualities

Highly motivated candidate with strong potential and a solid background in immunology.
Curious, proactive, and eager to contribute to a competitive international research environment.
Independent and capable of designing, executing, and managing research experiments while planning daily tasks.
Creative and able to develop and drive research ideas to successful outcomes.
Effective collaborator in multidisciplinary teams and across academic disciplines.
Comfortable working in large, complex organizational settings.
Excellent communication skills, including written, oral, and presentation abilities in English.

We offer

Involvement in a versatile and ambitious set of research projects.
A challenging, stimulating, and attractive work environment.
A salary in accordance with the guidelines of Oslo University Hospital.
Opportunities and support for career development.

Kontaktinformasjon

Jo Waaler, Group Leader, Researcher; PhD, jo.waaler@medisin.uio.no

Arbeidssted

Sognsvannsveien 9
0372 Oslo

Nøkkelinformasjon:

Arbeidsgiver: Oslo universitetssykehus HF

Referansenr.: 4895174673
Stillingsprosent: 100%
Temp
Søknadsfrist: 29.01.2025

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