Researcher on pyrimidine modifications in early life decisions, in development and for healthy aging

About the position

A researcher position on pyrimidine modifications in early life decisions, in development and for healthy aging is available in the lab of Hilde Nilsen. The lab is affiliated with the Centre for Embryology and Healthy Development (CRESCO) at the University of Oslo.

CRESCO is a Norwegian Centre of Excellence comprising an interdisciplinary team of researchers with expertise in epigenetic and epitranscriptomic modifications, DNA repair and genome (in)stability, and single-cell and single-nucleotide analyses, development including genome stability, chromosome segregation and retrotransposon activity. The position is offered as a permanent position for the duration of the Centre, ending in 2033.

More about the position

The specific project will focus on the role of pyrimidine modifications in early life decisions, in development and for healthy aging.
The candidate will design dedicated analyses pipelines for various omics technologies (RNA sequencing, ChIP sequencing, tagmentation techniques) that support method development in the Centre. The candidate will also develop innovative methods for multiomic data integration and visualizations as well as analyze multidimentional data from low-input applications, extremely low abundant base modifications, spatial, and single-cell sequencing technologies. Analyses will be conducted in both a single time point perspective as well as a longitudinal one. The candidate will take a special responsibility for bioinformatic competence building and knowledge dissemination within the Centre. 

The candidate will work in an ambitious team of computational biologists, molecular biologists and clinicians to generate synergies within the Centre

Duties of the position

The candidate will design dedicated analyses pipelines for various omics technologies (RNA sequencing, ChIP sequencing, tagmentation techniques) that support method development in the Centre. The candidate will also develop innovative methods for multiomic data integration and visualizations as well as analyze multidimentional data from low-input applications, extremely low abundant base modifications, spatial, and single-cell sequencing technologies. Analyses will be conducted in both a single time point perspective as well as a longitudinal one. The candidate will take a special responsibility for bioinformatic competence building and knowledge dissemination within the Centre.

Qualifications

We seek a highly motivated candidate who is excited about developing new computational models and tools with applications in basic science and translational medicine and in supporting and teaching bioinformatics to molecular biologists. The ideal candidate is collaborative and creative, has strong programming skills, can prove formal training in biology and/or medicine at BSc/MSc level in addition to a PhD in bioinformatics and is willing to work in a multidisciplinary team. The candidate must be able to handle multiple sub-projects and tasks at the same time and have demonstrated the ability to deliver data and results according to set timelines. Experience with analysis of a wide range of -omics data (RNAseq, scRNA seq, BLISS sea, Cut-Tag) is a requirement for this position. We are looking for an individual who is excited about developing and using computational methods to answer specific hypotheses all while disseminating the analyses clearly. 

Required selection criteria

• Appointment to the position of researcher in position code 1109 requires a doctoral degree in bioinformatics/computational biology.
• Extensive experience with analysis of -omics data (RNAseq, scRNA seq, ATACseq, BLISS sea, Cut-Tag data for low input or ultra-rare base modifications), including data from high-throughput sequencing techniques.
• Extensive experience with analyses of high dimension and longitudinal data, preferably, transcriptomic data.
• Extensive experience with working in multi-disciplinary teams (bioinformatics, medicine, and molecular biology).
• Proficiency in programming with both Python and R.
• Proficiency in UNIX/Linux and Bash/Shell scripting
• Ability to work with large computing clusters
• Excellent English written and verbal communication skills
   

The following qualifications will be considered desirable:

A degree in biology or (bio)medicine in addition to bioinformatics.
Knowledge of statistical data analysis and/or machine learning.
Experience in the development of analysis pipelines.
 

Personal qualities

• Strong analytical ability and curiosity-driven approach to research 
• Ability to work both independently and collaboratively in an interdisciplinary research environment
• High level of motivation, responsibility, and persistence
• Clear and constructive scientific communication skills
   

We need different perspectives in our work 

UiO is an open and internationally oriented comprehensive university that strives to be an inclusive and diverse workplace and academic environment. You can read more about UiO’s work on equality, inclusion, and diversity at uio.no.

We fulfill our mission most effectively when we draw upon our variety of experiences, backgrounds, and perspectives. We are looking for great colleagues—could you be the next one?

We will do our best to accommodate your needs. Relevant adjustments may include modifications to working hours, task adaptations, digital, technical, or physical adjustments, or other practical measures.

If you have an immigrant background, a disability, or CV gaps, we encourage you to indicate this in the job application portal. We always invite at least one qualified candidate from each group for an interview. In this context, disability is defined as an applicant who identifies as having a disability that requires workplace or employment-related accommodations. For more details about the requirements, please refer to the Employer portal (Norwegian).

The selections made in the job application portal are used for anonymized statistics that all state employers include in their annual reports.

More information about gender equality initiatives at UiO can be found here.

We hope you will apply for the position with us. 

We offer

• Exciting and meaningful tasks in an organization with an important societal mission, contributing to knowledge development, education, and enlightenment that promote sustainable, fair, and knowledge-based societal development.
• A stimulating and safe working environment and participation in one of Norway's best research environments
• Vibrant international academic environment
• Good welfare schemes.
• Opportunity of up to 1.5 hours a week of exercise during working hours.
• A workplace with good development and career opportunities. 
• Membership in the Statens Pensjonskasse, which is one of Norway's best pension schemes with beneficial mortgages and good insurance schemes.
• Salary in position as Researcher, position code 1109 in salary range NOK from 690 000 to 770 000, depending on competence and experience. From the salary, 2 percent is deducted in statutory contributions to the State Pension Fund.

 

Read more about the benefits of working in the public sector at Employer Portal.

Application

Your application should include:

• Cover letter, stating your motivation, scientific background, and research interests 
• CV.
• A complete list of publications.
• Transcripts and certificates.
• Contact information for 2-3 references.

Application with attachments must be submitted via our recruitment system Jobbnorge, click "Apply for the position".

When applying for the position, we ask you to retrieve your education results from Vitnemålsportalen.no. If your education results are not available through Vitnemålsportalen, we ask you to upload copies of your transcripts or grades. Please note that all documentation must be in English or a Scandinavian language.

General information

The best qualified candidates will invited for interviews.

Applicant lists can be published in accordance with Norwegian Freedom of Information Act § 25. When you apply for a position with us, your name will appear on the public applicant list. It is possible to request to be excluded from this list. You must justify why you want an exemption from publication and we will then decide whether we can grant your request. If we cannot, you will hear from us.

Please refer to  Rules for the use of research posts SKO 1108, 1109, 1110 and 1183 at UiO.

The University of Oslo has a transfer agreement with all employees that is intended to secure the rights to all research results etc.