Researcher in Cell Therapy Process Development 

A 2-year position as a researcher is available at the Centre for Advanced Cell Therapy (ACT), Oslo University Hospital, under the supervision of the ACT Director Anna Pasetto. The position will be located at the pre-GMP facility at the Norwegian Radium Hospital, Oslo.

The ACT Centre is a core facility and translational research environment dedicated to accelerating the development and clinical implementation of advanced cell therapies. We are looking for a highly motivated candidate with a strong interest in translational cell therapy, process development, and quality control methods for advanced therapy medicinal products.

About the project
The successful candidate will work on the optimization and development of manufacturing and quality control processes for cell therapy products. The project will involve the development, testing, and implementation of new protocols for cell therapy manufacturing, analytical characterization, and potency/functionality assessment. A key focus will be the introduction and evaluation of automated solutions for manufacturing and QC workflows, in close collaboration with national and international academic and industry partners. The work will be performed in the pre-GMP facility at the Norwegian Radium Hospital and will support the translation of innovative cell therapy approaches towards clinical application.

Oslo University Hospital is a workplace with great diversity. We believe this is crucial to solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and encourage all qualified candidates, regardless of background, to apply.

Main tasks

• Develop and optimize manufacturing protocols for cell therapy products, including T cells, NK cells, iPSC-derived products, or related cell platforms.
• Establish and validate analytical methods for cell therapy process development.
• Perform advanced cell culture, expansion, activation, differentiation and genetic modification workflows, depending on the project needs.
• Design and perform functionality assays relevant to cell therapy products.
• Use multiparameter flow cytometry for phenotypic and functional characterization.
• Apply molecular biology methods; experience with ddPCR is considered an advantage.
• Contribute to the evaluation and implementation of automated systems for manufacturing and QC.
• Collaborate with industry partners and multidisciplinary teams within ACT and Oslo University Hospital.
• Contribute to documentation, reporting, publication of results, and preparation of protocols relevant for translational and clinical development.

Qualifications

The applicant must hold a PhD in immunology, cell biology, biotechnology, molecular biology, biomedical sciences, or a related discipline.
The ideal candidate has:

• Hands-on experience with translational cell therapy research and/or process development.
• Practical experience with cell therapy platforms such as T cells, NK cells, iPSC-derived cells, or similar advanced cellular products.
• Strong expertise in mammalian cell culture and cell-based functional assays.
• Documented experience with flow cytometry, including assay design, acquisition, and data analysis.
• Experience with basic molecular biology techniques.
• Experience with ddPCR, cell therapy manufacturing workflows, automated platforms, or GMP/pre-GMP environments will be considered an advantage.
• Good understanding of the requirements for translation of cell therapy products towards clinical use.
• Excellent communication and teamwork skills.
• Ability to work independently, systematically, and in a multidisciplinary environment.
• Good written and oral English skills.

Personal qualities

We are looking for a candidate who is scientifically curious, technically skilled, solution-oriented, and motivated to contribute to the clinical translation of advanced cell therapies. The candidate should enjoy working in a collaborative environment and be comfortable interacting with academic researchers, clinical teams, technical staff, and industry partners.

We offer

• A 2-year full-time researcher position in a highly translational and international cell therapy environment.
• The opportunity to work at the interface between research, process development, manufacturing, QC, and clinical translation.
• Access to state-of-the-art infrastructure at the ACT Centre and the pre-GMP facility at Radiumhospitalet.
• Collaboration with leading academic and industry partners in the field of advanced cell therapy.
• A stimulating, multidisciplinary workplace at Oslo University Hospital.
  

The position is based at the Norwegian Radium Hospital, Oslo University Hospital.

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