PhD candidate position in the Genomic stability and Health group
Jobbnorge ID: 187747
Job description
A funded 3-year PhD candidate position is available in the Genomic stability and Health group led by Hilde Loge Nilsen at the Department of Clinical Molecular Biology (EpiGen), Faculty of Medicine, University of Oslo, Norway. EpiGen is localised at the Akershus University Hospital campus.
For more information:https://www.med.uio.no/klinmed/english/about/organization/divisions/medicine-laboratory-sciences/clinical-molecular-biology/index.html
The group focus is to define how maintenance of nucleic acids (DNA and RNA) impact aging and disease development using a wide range of tools (genetic, cell biological and computational). We are now seeking a PhD candidate to work in a subgroup that studies the origin of mutations in cancer. The specific project, which is funded by EUROSTARS, seeks to develop intervention strategies that halt the molecular evolution processes that lead to B-cell lymphoma.
The candidate will perform standard RNAseq analyses on data generated from cell and animal models of B-cell lymphoma such as differential gene expression patterns, pathway enrichment, and pathway deregulation scores. In addition to standard analyses, the candidate will build a pipeline to perform variant calling from RNAseq data and use statistical tools to define specific features in the datasets.
The candidate will also analyze data generated, initially, using the Illumina TruSight oncology 500 panel and build a pipeline to identify specific features, such as mutation signatures as biomarkers of mutation generating processes from tumour panel sequencing data.
The candidate
We seek a highly motivated candidate who is excited about developing new computational models and tools and its applications in translational medicine. The ideal candidate is collaborative and creative, has strong programming skills and is willing to work in a multinational team. The candidate must be able to handle multiple sub-projects and tasks at the same time and have demonstrated ability to deliver data and results according to set time-lines. Experience with analysis of genomic data is a requirement for this position. We are looking for an individual who is excited about developing and using computational methods to answer specific hypotheses in cancer evolution.
Qualification requirements
- Master's degree or equivalent in bioinformatics, computational biology, informatics, biostatistics or a related field
- Foreign completed degree (M.Sc.-level) has to correspond to a minimum of four years in the Norwegian educational system. Applicants who do not have a degree yet, but who are expecting to graduate this summer/fall can apply to this position.
- Applicants with a background in biology or (bio)medicine with a strong programming background and experience in `omics data analysis are also encouraged to apply.
- Experience with (or interest in) analysis of genomics data, including data from high-throughput sequencing techniques.
- Proficiency in programming (preferably Python)
- Proficiency in UNIX/Linux and Bash/Shell scripting
- Knowledge of statistical data analysis and/or machine learning, including the use of R
- Excellent English written and verbal communication skills
The following qualifications will be considered desirable:
- Experience with analyses of exome or amplicon sequencing, and preferably transcriptomic data
- Experience in single-cell analyses
- Experience in software development
We offer
- A stimulating research environment
- Salary NOK 479 600 - 532 300 per annum in a position code SKO 1017, depending on qualifications
- Favourable pension arrangements (Statens Pensjonskasse)
- Advantageous welfare conditions
How to apply
The application must include:
- Cover letter, stating your motivation, scientific background, and research interests,
- A detailed CV, 2-3 references (name, institution, e-mail, telephone number, and relation to the candidate)
- Copies of diplomas and transcripts.
The application with attachments must be submitted in English and uploaded in pdf format in our electronic recruiting system linked in the announcement. Please follow the link "apply for this job".
While the recruitment system includes a basic CV, we ask candidates to also include a separate, detailed CV in pdf format with their application. Applications without a cover letter and detailed CV will be rejected.
When evaluating the application, emphasis will be given to the eventuelt "project description" and the applicant's academic and personal prerequisites to carry out the project. Applicants may be called in for an interview.
Formal regulations
The PhD candidate must take part in the University's approved PhD program and is expected to complete the project within the set fellowship period.
For more information https://www.med.uio.no/english/research/phd/
Please see the guidelines and regulations for appointments to Research Fellowships at the University of Oslo.
No one can be appointed for more than one PhD Research Fellowship period at the University of Oslo.
According to the Norwegian Freedom of Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure.
The appointment may be shortened/given a more limited scope within the framework of the applicable guidelines on account of any previous employment in academic positions.
The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.
Contact information
For any informal enquiries regarding the position, please contact Head of department, professor Hilde Nilsen E-mail: h.l.nilsen@medisin.uio.no Telephone: +47 93246618 or Dr. Diana Domanska dianadom@uio.no Telephone: +47 93825890
For questions regarding the application process, please contact HR adviser Svetlana Trofimova, tel. +47 22859226, e-mail: svetlana.trofimova@medisin.uio.no
Se annonsen og søk på stillingen www.jobbnorge.no
Om bedriften
The University of Oslo is Norway's oldest and highest ranked educational and research institution, with 28 000 students and 7000 employees. With its broad range of academic disciplines and internationally recognised research communities, UiO is an important contributor to society.
The Institute of Clinical Medicine (Klinmed) is one of three institutes under the Faculty. Klinmed is responsible for the Faculty's educational and research activities at Oslo University Hospital and Akershus University Hospital. With about 800 employees spread over approximately 425 man-labour years, Klinmed is the university's largest institute. Our activities follow the clinical activity at the hospitals and are spread across a number of geographical areas.
The Department of Clinical Molecular Biology , Division of Medicine and Laboratory Sciences at Akershus University Hospital, is a joint research facility between Akershus University Hospital and the University of Oslo, Faculty of Medicine. The goal of the Department is to perform research at the international research front that integrates high- quality basic and clinical/translational research. The Department has modern, well-equipped research laboratories for basic research, as well as for clinical molecular biology. Research in the Department is focused on areas of molecular medicine pertaining to the major age-related diseases, which is reflected in the strategic focus on healthy aging at Akershus University Hospital.